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KMID : 1098420070150060434
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 6 p.434 ~ p.436
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Action of Rodgersia podophylla Root Extracts on Melanin Biosynthesis in Skin
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Kong Yeon-Hee
Choi Sang-Yoon
Lee Pyeong-Jae
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Abstract
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In the previous study, we reported the inhibitory effects of Rodgersia podophylla root extract on tyrosinase activity and melanin production in melan-a cells. However, mechanism of the inhibitory activity and in vivo assay were not yet examined. This study performed the examination of the effects of Rodgersia podophylla root extract on protein expression and in vivo depigmenting activity using melan-a cells and brown guinea pigs. As the results of western immunoblotting analysis, treatment of Rodgersia podophylla root extract reduced tyrosinase expression rates in 10 and 100 ppm concentrations, dose dependently. Moreover, Rodgersia podophylla root extract exhibited depigmenting activity on UV-B induced hyperpigmentation in brown guinea pig skin. These results suggested that Rodgersia podophylla root extract could act as whitening agent for the skin via not only direct tyrosinase activity inhibition but also reducing of tyrosinase expression.
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KEYWORD
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Rodgersia podophylla, melanogenesis, brown guinea pig
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